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목적 : To investigate microbiological profile, antibiotics susceptibiity and resistance, and treatment outcome in patients with bacterial keratitis from 2007 to 2015 in a tertiary medical center in Korea.
방법 : Retrospective review of electronic medical records of patients who had culture-proven bacterial keratitis in Seoul National University Hospital from 2007 to 2015. The microbiological profile and antibiotics resistance were compared between isolates from 2007 to 2011 and those from 2012 to 2015. The treatment outcome and prognosis were also evaluated.
결과 : Gram positive bacterial infection accounted for 60.8% of patients with gram positive cocci being the most common (50.0%). Staphylococcus aureus was the most common gram positive isolate (14.8%), and Pseudomonas aeruginosa the most common gram negative isolate (12.1%). All gram positive isolates were sensitive to vancomycin, and hopwever, 50.0% of gram positive isolates were resistant to oxacllin and 15.0% resistant to ciprofloxacin. All gram negative isolates were sensitive to meropenem, imipenem, and ceftazidime, while 7.14% of gram negative isolates were resistant to ciprofloxacin.
결론 : Gram positive cocci remained the majority of microorganisms isolated from bacterial keratitis, but an increasing prevalance of gram negative bacilli infection was noted. All gram positive isolates were sensitive to vancomycin, and all gram negative isolates were sensitive to carbapenem and ceftazidime
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