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목적 : To identify ocular parameters corresponding to asymmetric visual field (VF) loss in normal tension glaucoma (NTG) through intereye comparisons.
방법 : Bilateral NTG patients with asymmetric and symmetric VF loss were included in the study and their medical records were reviewed. The criterion for asymmetry in VF test was 6 dB difference of mean deviation. Refractive error, untreated initial intraocular pressure (IOP), central corneal thickness, ovality index, and peripapillary atrophy (PPA)/disc area ratio were obtained from each patient. Intereye comparison was performed for the asymmetric group, symmetric group, and myopic and nonmyopic asymmetric subgroups.
결과 : 119 asymmetric and 47 symmetric cases were enrolled. In intereye comparison for asymmetric group, initial IOP, ovality index, and PPA were significant factors. For myopic subgroup, refractive error(P=0.004), ovality index(P=0.001), and PPA(P=0.003) were significant factors. For nonmyopic subgroup, initial IOP(P=0.004) and PPA(P=0.007) were significant factors. In multivariate analysis, refractive error(P=0.002) and PPA(P=0.021) were significant in myopic subgroup, and initial IOP(P=0.028) and PPA(P=0.001) were significant in nonmyopic subgroup. Symmetric group showed no significant difference.
결론 : In this intereye comparison, the more myopic eye in myopic NTG patient, and the more pressured eye in nonmyopic NTG patient demonstrated more severe VF loss. Myopic and nonmyopic patients may follow different pathophysiologic processes. Discriminative attentions should be paid to NTG patients by subtypes.
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