|
목적 : To investigate factors associated with the focal γ-zone parapapillary atrophy (γPPA) by using spectral-domain optical coherence tomography (SD-OCT).
방법 : A total of 52 eyes of 52 glaucoma patients with ßPPA, an area without retinal pigmented epithelium detected by SD-OCT were enrolled. According to the extent of Bruch’s membrane(BM) within the βPPA, PPA was divided into 3 groups: 1) γPPA negative group(intact BM; 16 eyes), 2) diffuse γPPA group(PPA with an area without BM involving the fovea and BM opening(fovea-BMO) axis; 20 eyes), 3) focal γPPA group(PPA with an area without BM not involving the fovea-BMO axis; 16 eyes). Parameters including age, axial length, visual field mean deviation, focal lamina cribrosa defects were compared.
결과 : Eyes of the diffuse γPPA group were significantly younger and had significantly longer axial length than that of the γPPA negative and focal γPPA groups (47.6 vs. 66.1 and 62.2 years for age and 27.4 vs. 23.9 and 23.4 mm for axial length, P < 0.001, respectively) Eyes of the focal γPPA group had significantly higher prevalence of the focal lamina cribrosa defects than the γPPA negative and diffuse γPPA groups (87.5 vs. 20.0 and 12.5%, P < 0.001). Visual field mean deviation was not different among the 3 groups (P > 0.05, respectively).
결론 : Clinical characteristics of the focal γPPA were differentiated from the typical γPPA by older age and shorter axial length. Furthermore, eyes with focal γPPA had higher prevalence of the focal LC defects than other types of the βPPA. Longitudinal studies are warranted to elucidate whether focal LC defects and the focal γPPA share a common pathogenic mechanism.
|