| 발표일자: |
2017년 4월 15일(토) 10:00 ~ 4월 16일(일) |
| 발표번호: |
P(e-poster)-019 |
| 발표장소: |
광주 김대중컨벤션센터 |
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| Posterior Lamina Cribrosa Bowing is greater in Eyes with Primary Open-Angle Glaucoma than in Contralateral Healthy Eyes |
| 1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
2Department of Biomedical Engineering, National University of Singapore, Singapore
3Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
4Universit´e de la Polyn´esie Fran¸caise, Tahiti, French Polynesia
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| Jeong-Ah Kim MD,1 Tae-Woo Kim, MD,1 Eun Ji Lee, MD1, Micha¨el J. A. Girard,2, 3 and Jean Martial Mari4 |
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목적 : To investigate inter-eye differences in the degree of posterior lamina cribrosa (LC) bowing in unilateral primary open-angle glaucoma (POAG).
방법 : Bilateral optic nerves from 122 treatment-naive unilateral POAG patients were scanned using spectral-domain optical coherence tomography (SD-OCT). The magnitude of posterior LC bowing assessed by measuring LC curvature index (LCCI) was measured at 3 equidistant planes (superior midperipheral, midhorizontal, and inferior midperipheral). The relationship between the degree of LCCI and presence of glaucoma was analyzed, and the factors associated with the presence of glaucoma were determined.
결과 : Eyes with POAG showed greater LCCI than contralateral healthy eyes in superior midperipheral and inferior midperipheral plane (9.65 ± 2.41 vs. 8.00 ± 2.29 and 10.43 ± 2.89 vs. 8.60 ± 2.20, respectively, both Ps ≤ 0.001) together with higher IOP (P =0.007) and higher myopia (P = 0.025). In multivariate regression analysis, greater LCCIs in superior midperipheral and inferior midperipheral plane were revealed as significant factors associated with the presence of glaucoma (both Ps < 0.001).
결론 : The degree of posterior lamina cribrosa bowing was greater in eyes with POAG than contralateral healthy eyes. This finding supports that posterior bowing of LC is main pathomechanism of glaucoma development and LCCI may be a useful biomarker of the LC strain in eyes with glaucoma.
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