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목적 : To evaluate the association of C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) in Korean individuals with exfoliation syndrome (XFS) and to investigate those SNPs’ correlations with XFS phenotypes.
방법 : A total of 101 Korean XFS patients and 154 control subjects were included in this study. Five CRP SNPs, namely rs1205, rs1130864, rs1800947, rs1417938 and rs2794521, were genotyped using the TaqMan® allelic discrimination assay. A case-control association study on the allelic and genotypic frequencies of each SNP was performed, and the phenotypic features of XFS were compared in terms of those SNPs.
결과 : Of the five CRP SNPs selected for the study, none showed any significant allele or genotypic frequency differences between the XFS patients and control subjects. Also, a subgroup analysis revealed that none of the four SNPs of CRP were associated with other relevant XFS phenotypes, including bilateral involvement of XFS or the development of glaucoma.
결론 : Even though increased serum CRP level have been suggested as markers of inflammation and peripheral endothelial dysfunction in XFS, our data suggest that for Korean subjects, variants in CRP genes have negligible effects on the development of XFS.
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