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목적 : To investigate the effect of topical lubricants on tear film and ocular surface in dry eye patients depending on serum 25-hydroxyvitamin D levels.
방법 : A total of 116 patients with dry eye syndrome, treated from June 2015 to June 2016 were included. The subjects were divided into two groups according to serum 25-hydroxyvitamin D levels: vitamin D deficiency group (<12 ng/mL) and non-VDD group (≥12 ng/mL). Tear break-up time (TBUT), Schirmer’s tear secretion test, fluorescein staining score (FSS), ocular surface disease index (OSDI), and visual analogue pain score (VAS) were compared between base line and 2 weeks after topical application of liposic edo and hyaluronate. Serum 25-hydroxyvitamin D concentration was measured.
결과 : Mean age was 55.08 ± 12.38 years. OSDI and VAS in both groups decreased after topical lubricants compared to baseline (p < 0.05). TBUT in VDD group was not different after topical lubricants whereas TBUT in non-VDD group increased after topical lubricants(p = 0.001). FSS in VDD group was not different after topical lubricants whereas FSS in non-VDD group decreased after topical lubricants(p = 0.030). Lid margin hyperemia in VDD group was not different after topical lubricants whereas that in non-VDD group decreased after topical lubricants(p = 0.012).
결론 : Effect of topical lubricants depends on serum 25-hydroxyvitamin D levels. Vitamin D supplementation can be a useful adjuvant therapy in patients with dry eye syndrome refractory to topical lubricants.
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