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목적 : To compare the capability of the lamina cribrosa depth (LCD) and lamina cribrosa (LC) curvature in discriminating between eyes with primary open-angle glaucoma (POAG) and healthy eyes, in an attempt to evaluate their potential usefulness as a biomarker of optic nerve head (ONH) connective tissue strain.
방법 : The LCD and lamina cribrosa curvature index (LCCI) were measured in B-scan images obtained using swept-source optical coherence tomography at seven locations. The LCD was defined as the distance from the level of Bruch’s membrane opening (BMO) to the anterior LC surface. The LCCI was calculated by dividing the lamina cribrosa curve depth (LCCD) by the width of LC surface reference line (W) and multiplying by 100. The LCCD was defined as maximum distance from the LC surface reference line connecting the two points on the anterior LC surface to the anterior surface of the LC.
결과 : Seventy-seven eyes of 77 patients with POAG and 77 eyes of 77 healthy subjects who were matched for age, gender, and axial length were included.The average LCD (P<0.001) and average LCCI (P<0.001) were significantly larger in POAG eyes than in the matched healthy subjects (all seven locations, P<0.001). The AUC was significantly larger for the LCCI than the LCD (0.921 vs 0.784, P<0.001). The intraocular pressure was positively associated with average LCD and LCCI in healthy subjects (P=0.021 and P<0.001, respectively) and POAG patients (P=0.011 and P<0.001, respectively).
결론 : LCCI had significantly better discriminating capability between POAG and healthy eyes than LCD. This finding suggests that the LCCI may serve better than the LCD as a biomarker of glaucomatous ONH strain.
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