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목적 : The purpose of this study is to investigate the correlation between PERG amplitude and macular GCL thickness and to compare it with the previous study results.
방법 : This is a retrospective, cross-sectional comparative study. PERG was recorded using a commercial ERG system. P50 amplitude was measured from the trough of N35 to the peak of P50. SITA 24-2 perimetry of the Humphrey Visual Field Analyzer 750 was used. VF total deviation values were recorded in all 52 testing points and among these points, central 13 points corresponding to the macular area were selected and averaged. The commercial Cirrus SD-OCT was used to evaluate thickness of ganglion cell layer. Using broken-stick, linear and quadratic regression model was used to correlation analysis.
결과 : 104 subjects were recruited for the study: 54 healthy and 50 glaucoma subjects. The mean PERG amplitude of healthy / glaucoma subjects was 7.51 ± 2.14 µV / 5.79 ± 2.21 µV and was significantly different. In the correlation analyses, the Broken-stick model was best fitted. PERG amplitude was weakly but significantly correlated with GC-IPL thickness. (R square=0.2201, P=0.024) Visual field was relatively better correlated with PERG amplitude than GC-IPL. (R square=0.2510, P<0.001) The expected tipping point in central visual field was 1.660 µV, 78.07% lower than normal value in our study.
결론 : PERG amplitude was weakly but significantly correlated with macular GC-IPL thickness. The best fitted statistical model was broken-stick model and this means that before substantial thinning of GC-IPL, PERG amplitude begins to attenuate. The more considerable loss of PERG amplitude, about 78.07% loss from normal amplitude, is required to be visual field loss started. PERG amplitude can help clinicians make early decision of the reliable treatment plan before any structural damage or visual field abnormality detected.
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