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목적 : To compare the shape, area of foveal avascular zone (FAZ) and parafoveal vascular density (PVD) between glaucomatous eyes and healthy controls determined by optical coherence tomography angiography (OCTA) and to assess the structure-function relationships between foveal parameters and retinal sensitivities (including central retinal sensitivities) in healthy and early glaucoma subjects with and without central visual field defect (CVFD) (Mean Deviation; MD<-10dB).
방법 : Total 115 eyes, including 39 glaucomatous eyes with CVFD, 34 glaucomatous eyes without CVFD, and 42 control eyes, were enrolled. Circularity, area of FAZ, and PVD were measured by OCTA. Central retinal sensitivity was calculated by anti-log absolute (1/L) sensitivity values of 12 central point of VF 24-2 test. Macular GCIPL thickness was measured by SD-OCT. Structure-function relationships among FAZ parameters, PVD, and average mGCIPL thickness adjusted by age, and global (MD) and central VF retinal sensitivity were calculated. Factors associated with CVFD were determined.
결과 : Glaucomatous eyes with CVFD showed lower FAZ circularity, larger FAZ area, and lower GCIPL thickness than other two groups. Correlations were found among FAZ circularity and area and mGCIPL thickness and central VF sensitivity (all P<0.05, adjusted by age). Among glaucomatous eyes with CVFD, corresponding hemiretinas showed lower central retinal sensitivity (1/L), larger hemi-FAZ area, lower parafoveal vascular density, and thinner mGCIPL thickness than those of opposite hemiretinas (all P<0.001). PSD, FAZ circularity, and mGCIPL thickness were significantly associated with CVFD.
결론 : Early glaucomatous eyes with CVFD showed enlarged, irregular-shaped FAZ on OCTA. Parafoveal vascular density was selectively reduced according to the location of CVFD. Lower FAZ circularity and GCIPL thickness were significantly associated with the presence of CVFD.
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