| 망막F-041 |
| 삼출성 나이관련황반변성으로 진단받고 3회 라니비주맙 주입술 후 재발이 없는 환자들의 장기 예후 |
| 건양대학교 의과대학 김안과병원 안과학교실 명곡안연구소 |
| 김재민, 김재휘, 김종우, 김철구, 이동원, 한정일, 유수진 |
|
목적 : To evaluate long-term changes in visual acuity and retinal microstructure in patients with neovascular age-related macular degeneration (AMD) who had maintained dry macula after initial treatment.
방법 : This retrospective observational study included 55 eyes that were diagnosed with neovascular AMD, were treated with 3 monthly ranibizumab injections, and maintained dry macula during 2-year follow-up. Best-corrected visual acuity (BCVA) at 3 months and at the final follow-up was compared, and the degree of visual improvement was compared between eyes with and without improvement of the ellipsoid zone. In addition, the incidence of improvement of the ellipsoid zone was compared between eyes with different extents of disruption.
결과 : The mean follow-up period was 30.3 ± 4.1 months. BCVA at 3 months and at the final follow-up was 0.51 ± 0.46 and 0.45 ± 0.49 (P < 0.001). Among 35 eyes that exhibited >200 μm of disruption of the ellipsoid zone, 15 (42.9%) showed improvement of the ellipsoid zone, and the improvement in BCVA was greater in these eyes than that in the remaining 20 eyes (P = 0.021). A higher incidence of improvement of the ellipsoid zone was noted in eyes with 200 to 800 μm of disruption than in eyes with >800 μm of disruption (P < 0.001).
결론 : Long-term improvement in visual acuity was noted in eyes that had maintained dry macula after 3 ranibizumab injections. The status of the ellipsoid zone at 3 months was closely associated with visual improvement.
|
| |