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목적 : To investigate changes in disease activity after a massive hemorrhage in polypoidal choroidal vasculopathy (PCV).
방법 : Retrospective, interventional, comparative, case series.
Fifty-two PCV eyes of 52 patients were included: 36 eyes with massive hemorrhage at baseline (Group1) and 19 eyes with newly developed hemorrhage during treatment (Group 2). Thirty age- and lesion size-matched PCV eyes without subretinal hemorrhage were enrolled as controls. Injection numbers and clinical factors that affect recurrent fluid and hemorrhage were analyzed.
결과 : The number of injections was 2.5 ± 2.2/year after hemorrhage in the hemorrhagic group and 5.7 ± 2.7/year in the control group (P < .001). In Group 2, the number of injections before hemorrhage was 6.0 ± 3.5/year and was decreased significantly after hemorrhage (P = .009). Age at the onset of hemorrhage was greater in patients that required additional treatment within 1 year after the hemorrhage, compared to those who did not (P < .001) and disease-free period negatively correlated with age (P < .001, r2 = .270). Eyes with recurrent hemorrhage revealed multiple remaining polyps.
결론 : The lesion activity that required anti-VEGF treatment diminished after a subretinal hemorrhage in PCV eyes, and additional treatments may not be necessary. However, careful follow-up is still required since visual acuity can be preserved with timely treatment and recurrent hemorrhages can occur in eyes with cluster-type PCV.
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