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목적 : To investigate the association of 25-hydroxyvitamin D with AMD
방법 : A population-based, cross-sectional study using a nationwide, systemic stratified, multistage clustered sampling method involved a total of 17,045 subjects aged >40 years who participated in the Korean National Health and Nutrition Examination Survey 2008–2012. All participants underwent standardized interviews, evaluation of blood 25-hydroxyvitamin D levels, and comprehensive ophthalmic examinations. A 45° digital fundus photograph of both eyes was taken under physiologic mydriasis. All fundus photographs were graded using the international classification and grading system.
결과 : Blood 25-hydroxyvitamin D levels were 17.5 ng/mL in women and 20.0 ng/mL in men. After adjusting for potential confounders including age, sex, smoking status, hypertension, heart problems, stroke, and sunlight exposure time, the odds ratio (OR) for late AMD significantly decreased in the highest blood 25-hydroxyvitamin D quintile (OR, 0.32; 95% confidence interval [CI], 0.12–0.81; P for trend =0.018) compared with the lowest quintile in men, but not in women. Early AMD was not associated with blood 25-hydroxyvitamin D levels in either sex.
결론 : High level of blood 25-hydroxyvitamin D was inversely associated with late AMD in men but not women. Considering anti-angiogenic and anti-fibrotic action of vitamin D, association between two variables warrants further studies.
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