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목적 : Smoking is associated with prevalent age-related macular degeneration (AMD). However, the incidence of neovascular AMD among smokers has not been longitudinally well-evaluated because of the rarity of this disease. This study aimed to evaluate the association between cigarette smoking and neovascular AMD.
방법 : We conducted a nationwide historical cohort study involving Korean men aged 45–79 years included in the Korea National Health Insurance Service database from 2002 through 2013. Incident cases of neovascular AMD was identified from the database. We compared hazard ratios (HR) for neovascular AMD between 64,974 current/past and 64,974 never smokers by 1:1 propensity-matched analysis, and 85,288 current/past and 72,406 never smokers by unmatched cohort and propensity-adjusted analysis.
결과 : The risk of neovascular AMD in current/past smokers was higher than in never smokers (propensity-adjusted whole cohort analysis: HR, 1.50; 95% confidence interval [CI] 1.24–1.82; propensity-matched analysis: HR, 1.56; 95% CI, 1.28–1.91). This risk was more pronounced in current than past smokers (propensity-adjusted whole cohort analysis for current smokers: HR, 1.68; 95% CI, 1.36–2.06; for past smokers: HR, 1.18, 95% CI, 0.89-1.56; propensity-matched analysis for current smokers: HR, 1.66; 95% CI, 1.34–2.06; and for past smokers: HR, 1.36; 95% CI, 1.02–1.80).
결론 : There is a strong risk of neovascular AMD associated with smoking with the risk higher among current smokers than past smokers.
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