| 망막F-003 |
| 다발성신경계위축에서 임상적 중증도와 망막 두께 변화의 연관성 분석 |
| (1) 서울특별시보라매병원 안과, (2) 서울대학교 의과대학 안과학교실, (3) 서울특별시보라매병원 신경과, (4) 서울대학교 의과대학 신경과교실 |
| 안지윤(1,2), 김태완(1,2), 이지영(3,4) |
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목적 : To analyze retinal thickness changes in multiple system atrophy (MSA) and
correlate changes with disease severity and subtypes of MSA.
방법 : A total of 36 MSA (27 MSA-P and 9 MSA-C) patients and 71 healthy control
subjects underwent general ophthalmologic examination and optical coherence tomography
(OCT) scans. The Generalized Estimating Equation model was used
with age as a covariate to adjust for within-patient inter-eye correlations and the effect of age
on retinal or RNFL thickness. Correlation analysis between RNFL, perifoveal thickness and
clinical parameters, the Unified MSA Rating Scale (UMSARS) and Global Disability Score (GDS), was also done.
결과 : MSA patients showed significantly decreased peripapillary RNFL thickness in the
inferior (P=0.047) and inferotemporal (P=0.017) sectors and significant perifoveal thinning in
the superior outer sector (P=0.042) compared to healthy controls. Both RNFL and perifoveal
thinning were more marked and widespread in MSA-P than MSA-C patients. The UMSARS
and GDS showed a consistent and significant negative correlation with perifoveal thickness
(0.005 < P < 0.043).
결론 : Peripapillary RNFL and perifoveal retinal thinning was observed in MSA
patients and retinal thinning correlated with the clinical severity of MSA. Structural changes
in the retina may reflect the degree and pattern of neurodegeneration occurring in MSA.
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