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목적 : To study correlation between electrophysiologic examinations which evaluate visual functions with optical coherence tomography (OCT), an anatomical evaluation in patients with traumatic optic neuropathy.
방법 : Retrospective, observational case series study. Twenty eyes from patients diagnosed with traumatic optic neuropathy were included. Basic ophthalmologic examinations were performed. Pattern ERG (P50 amplitude, N95 amplitude and N95/P50 ratio) and pattern VEP (P100 amplitude and latency) were analyzed and compared with the thickness of peripapillary retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer complex measured with OCT.
결과 : 20 patients (17 male, 3 female) were evaluated. All parameters including P50 amplitude, N95 amplitude, N95/P50 ratio, P100 amplitude and P100 latency changed in the traumatic eye. When it comes to pattern ERG with visual acuity, N95/P50 ratio showed the significant correlation (r=0.517 p=.028). Although temporal RNFL thickness had a significant correlation with P100 amplitude of pattern VEP (r=-0.930, P<0.001), pattern ERG did not show a correlation with OCT. In the patients with no detectable pattern VEP, pattern ERG could be obtained in 7 out of 8 patients.
결론 : In patients with traumatic optic neuropathy, the pattern ERG may be a helpful alternative to pattern VEPs. ERG shows retinal function whereas VEP may reflect any abnormalities that affect visual pathway including visual cortex in the brain. Also in cases of flat VEP signals, results of ERG tend to achieve viable wave forms.
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