| 발표일자: |
2016년 11월 4일(금) ~ 11월 6일(일) |
| 발표번호: |
P(e-poster)-136 |
| 발표장소: |
킨텍스 제2전시장 7B홀 |
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| 외상성 맥락막 파열 후 발생한 맥락막 신생혈관의 항혈관내피성장인자항체 치료 효과 및 경과 |
| 서울대학교 의과대학 분당서울대학교병원 안과학교실(1), 울산대학교 의과대학 서울아산병원 안과학교실(2), 한림대학교 의과대학 강남성심병원 안과학교실(3), 서울특별시보라매병원 안과(4), 중앙대학교 의과대학 안과학교실(5) |
| 주광식(1), 엄태웅(2), 조준희(3), 안지윤(4), 김지택(5), 이주용(2), 박규형(1), 우세준(1) |
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목적 : Choroidal neovascularization (CNV) secondary to traumatic choroidal rupture is an unusual and therapeutic consensus has not been established. The aim of this study is to clarify the clinical efficacy and safety of anti-VEGF therapy in posttraumatic CNV.
방법 : Nine patients with secondary CNV after blunt trauma who received intravitreal injection of anti-VEGF agent were evaluated. We evaluated the effectiveness of anti-VEGF therapy using the best-corrected visual acuity (VA) and imaging modalities such as optical coherence tomography (OCT), OCT angiography and fluorescence angiography (FAG). In addition of our cases, all literatures associated with anti-VEGF therapy in posttraumatic CNV were reviewed and clinical manifestations were also analyzed.
결과 : The time intervals between trauma and CNV occurrence were variable from 1 week to 9 years and the median was 6 months. New onset blurry vision was main symptom and intraretinal edema was observed in most patients with incipient CNV. In all cases, VA, CNV-associated dye leakage and retinal edema were improved after anti-VEGF therapy. In 6 cases, complete resolutions of CNV were achieved by a single injection of anti-VEGF. In literature reviews, 9 of 10 patients received a single injection of anti-VEGF. VA improvement and resolution of CNV and retinal edema were observed in all cases.
결론 : In most cases, intravitreal anti-VEGF therapy improved visual acuity and relieved objective findings of posttraumatic CNV. Even single injection can lead to the complete resolution of CNV and fluid collection. In addition to the previous reports, this report suggests that intravitreal anti-VEGF therapy is considered as an effective and safe option for traumatic CNV.
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