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목적 : To evaluate the association between focal lamina cribrosa defect (FLCD) and the topographic characteristics of disc hemorrhage (DH), including area and location.
방법 : In vivo lamina cribrosa (LC) images were obtained by swept-source optical coherence tomography (SS-OCT) immediately following the detection of DH. Two masked graders identified FLCD (laminar holes or disinsertions >100 µm in diameter and >30 µm in depth) defined by a customized protocol using en face images and 12 radial-orientation raster scans of SS-OCT. En face image/stereo-disc photography overlay images were evaluated to determine the spatial relationship between the respective FLCD and DH locations.
결과 : We enrolled a total of 98 primary open-angle glaucoma (POAG) eyes with DH (98 subjects). Sixty-eight (68) of 98 eyes with DH (68.4%) had at least one FLCD. Thirty-eight (38) of those 68 eyes with DH and ≥1 FLCD (55.9%) had a DH corresponding to the FLCD location (within one-half clock-hour distance from the midline). The FLCD-correspondent DHs (39 DHs) showed significantly larger areas (0.092 ± 0.030 mm2; P < 0.001) and more proximally-located proximal ends (P < 0.028) than the non-correspondent ones (33 DHs; 0.065 ± 0.024 mm2 of area).
결론 : DHs that correspond to FLCD location tend to have larger areas and to be more proximally located than those without correspondence. This suggests that FLCD might affect the topographic characteristics of DH.
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