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목적 : To compare the changes in corneal histology and corneal hysteresis (CH) that occur after conventional trans-epithelial corneal collagen crosslinking (CXL) that uses continuous ultraviolet A (UVA), with those that occur after accelerated trans-epithelial CXL that uses pulsed UVA.
방법 : The right eyes of New Zealand white rabbits were treated using one of the two trans-epithelial CXL methods. The eyes were then divided into two groups on the basis of the trans-epithelial CXL method used: Group 1 (conventional trans-epithelial CXL using continuous UVA) and Group 2 (accelerated trans-epithelial CXL using pulsed UVA).
결과 : In both groups, an increase in CH was found after CXL, but the changes were not significant when compared with the baseline value. The corneal resistance factor and corneal-compensated intraocular pressure also remained unchanged in both groups after treatment. In both groups, the CXL effect reached the anterior-mid part of the corneal stroma. In Group 1, CXL mostly affected the anterior-mid part stroma, whereas Group 2 showed stromal keratocyte loss, as well as an acellular zone, in the deep stroma. More signs of keratocyte apoptosis were observed in Group 2 than in Group 1.
결론 : Accelerated trans-epithelial CXL using pulsed UVA induces considerably more keratocyte damage than conventional trans-epithelial CXL using continuous UVA; it also causes deep stromal damage.
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