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목적 : To investigate the effect of intravitreal bevacizumab injection for diabetic macular edema (DME) on the peripapillary retinal nerve fiber layer (RNFL) thickness using spectral-domain optical coherence tomography (SD-OCT).
방법 : This prospective longitudinal cohort study included 26 eyes of 26 patients with one bevacizumab injection for DME. The macular and peripapillary RNFL thicknesses were measured at baseline, 1 month, and 3 months after a bevacizumab injection. The macular thickness and global RNFL thickness profiles of the age-matched and diabetes duration-matched patients with diabetic retinopathy without DME and those without diabetic retinopathy were considered the control group. The macular and peripapillary RNFL thicknesses of the injection group were compared with those of the other two groups.
결과 : The six sectorial and global RNFL thicknesses were greater in the DME group than in the non-DME group or no diabetic retinopathy group (P<0.05). Macular thickness significantly decreased after 1 month, and it tended to increase after 3 months of follow-up. Concurrently, the RNFL thickness except thickness of the temporal sector decreased steadily during the 3 month follow-up. Temporal RNFL and PMB thickness tended to increase in the course of 3 months after 1 month of injection. The changes in macular and global RNFL thickness at the 3 month showed significant significant correlation (P=0.003)
결론 : The RNFL thickness generally increased in patients with DME, and the increment in RNFL thickness correlated with the degree of DME. A single intravitreal bevacizumab injection used to treat DME caused a significant decrement in peripapillary RNFL thickness after 1 month and 3 months of follow-up. While long-lasting DME resulted in RNFL thickening in all sectors, short-term DME aggravation mainly influenced the temporal RNFL thickness.
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