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목적 : To identify the risk factors for, and clinical features and treatment outcomes of aggressive posterior retinopathy of prematurity (APROP) in Korean infants.
방법 : From January 2009 to June 2015, medical records of 105 infants were reviewed retrospectively. The associated systemic and maternal risk factors were analyzed in infants with APROP (zone I/posterior zone II) and treatment requiring-non-APROP. 1 year anatomical outcomes were compared according to the severity of ROP and treatment modalities.
결과 : The total incidence of treatment-requiring ROP was 15.9% and amongst them, 77.1% were non-APROP while 22.9% were APROP. The mean GA at birth and BW in the APROP group were significantly lower than those in the non-APROP group. Chorioamnionitis was the risk factors for developing more severe ROP. Two infants with BW > 1,500g who developed APROP, happened have chorioamnionitis. Infants with APROP required heavier treatment, however, the anatomical outcomes were less favorable.
결론 : One fourth of all treatment-requiring ROP was APROP in our study. Small GA, low BW and the presence of chorioamnionitis were the risk factors for developing APROP. 2 Infants without growth restriction, with larger BW, also developed APROP, which suggests that perinatal infection/inflammation may contribute to the increased risk of APROP in premature infants.
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