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목적 : To evaluate the effect of optic disc tilt on the progression of glaucoma in myopic glaucomatous eyes
방법 : A total of 85 eyes in 85 myopic glaucoma patients followed for more than 3 years. The optic disc tilt ratio and torsional degree were estimated on disc photographs. Glaucomatous progression was determined by evaluating a whole series of retinal nerve fiber layer photographs by 3 glaucoma experts. All participants were categorized into 2 groups according to tilt ratio. Kaplan-Meier life-table analysis was used to compare the survival experiences between groups. The hazard ratios(HRs) for the associations between potential risk factors were determined using Cox proportional hazards modeling.
결과 : Among 85 eyes in 85 myopic glaucoma patients, 38 eyes (44.7%) demonstrated progression and 47 eyes (55.3%) were stable on follow-up. The mean disc tilt ratio was significantly smaller, and the prevalence of disc hemorrhage higher, in the progression than the stable group (p = 0.006, < 0.001, respectively). The cumulative probability of progression was 24.7% in the tilted group and 57.1% in the non-tilted group (p = 0.008). Disc hemorrhage was predictive of progression (HR = 5.907; p < 0.001), and the tilt ratio demonstrated a marginal association (HR = 0.116; p = 0.067).
결론 : Myopic eyes with tilted disc demonstrate a smaller probability of structural glaucomatous progression. Optic disc tilt may be protective against glaucoma progression, or tilted myopic glaucomatous eyes may have less progressive characteristic by nature.
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