|
목적 : To evaluate the diagnostic ability of segmented macular ganglion cell complex using the spectral domain optical coherence tomography (OCT) for detecting glaucoma and analyze topographic pattern of segmented thickness in open-angle glaucoma compared with healthy subjects.
방법 : Spectral domain OCT having automated segmentation technology was used to obtain Confocal Scanning Laser Ophthalmoscopy image with superimposed “8x8 Posterior Pole Grid”. The separate thicknesses of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL) and inner plexiform layer (IPL) were measured. Their diagnostic abilities including ganglion cell-inner plexiform layer (GCIPL; GCL + IPL), ganglion cell complex (GCC; RNFL + GCL + IPL) and circumpapillary retinal nerve fiber layer (cpRNFL) were compared to discriminate between normal and glaucoma.
결과 : The thicknesses of mRNFL, GCL, IPL and cpRNFL were all significantly thinner in patients with open-angle glaucoma compared with healthy subjects (all, P<0.05). Among the global average thicknesses, the global GCC, global mRNFL and global GCL were best able to discriminate between glaucoma and normal groups. The difference of AUROCs of mRNFL, GCL and cpRNFL did not reach statistical significance. However, the AUROC of GCL was significantly higher than that of GCIPL. The global IPL thickness had the least AUROCs and showed lower diagnostic performance than mRNFL, GCL, GCIPL, GCC (all, P<0.05).
결론 : The diagnostic ability of segmented mRNFL and GCL to discriminate normal and glaucoma eyes is high and comparable to cpRNFL thickness. The diagnostic performance of GCL was superior to that of GCIPL. The reduced thickness area of mRNFL, GCL and IPL showed different topographic pattern.
|