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목적 : To investigate the anti-scarring effects of pirfenidone on wound healing in a rabbit model of glaucoma drainage implant surgery.
방법 : Adult New Zealand white rabbits underwent glaucoma drainage device implantation. One eye was randomly assigned to receive postoperative intra-bleb injection of pirfenidone followed by topical application. The other eye underwent the same procedure but without the addition of pirfenidone. Histochemical staining and immunohistochemistry for blebs were performed.
결과 : The innermost collagenous layer was thinner in the pirfenidone group than the control group at 4 (P = 0.031) and 8 weeks (P = 0.022) postoperatively. The percentage of PCNA-positive cells was lower in the pirfenidone group than in the control group at 2 weeks postoperatively (P = 0.022). Pirfenidone treatment decreased expression of connective tissue growth factor at 2 weeks postoperatively (P = 0.029). The height and area of α-smooth muscle actin expression were lower in the pirfenidone group compared with the control group at 2, 4, and 8 weeks postoperatively (All P < 0.05).
결론 : Postoperative intra-bleb injection of pirfenidone followed by topical administration reduced fibrosis following glaucoma drainage device implantation. These findings suggest that pirfenidone may have a role as an anti-scarring agent in glaucoma drainage implant surgery.
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