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목적 : To investigate the clinical characteristics of patients with anterior hypertensive uveitis, and to compare characteristics between patients in cytomegalovirus (CMV)-positive and CMV-negative groups in their aqueous humor samples.
방법 : Immunocompetent patients (n=42) with a history of chronic and/or recurrent hypertensive anterior uveitis underwent ophthalmic examination and serological tests. Among the 42 patients with hypertensive anterior uveitis, aqueous humor sampling was performed in 22, and they were analyzed for viral deoxyribonucleic acids using the polymerase chain reaction (PCR).
결과 : The mean age of the 42 patients was 57.6±4.0yrs, and 29 (69.0%) of the subjects were males. Of total 42 patients, 22 (52.4%) underwent glaucoma surgery, and the average corneal endothelial cell counts were 1,908 cells/mm2. Among the 22 patients who underwent an aqueous sampling, 6 were positive for CMV-DNA, while 16 were negative. 66.7% of the CMV-positive group underwent glaucoma tube shunt surgery, whereas 80 % of the CMV-negative group underwent trabeculectomy for glaucoma surgery(P=0.095). The corneal endothelial cell counts were significantly lower in the CMV-positive group(P=0.009).
결론 : CMV was found to be an etiological factor in patients with hypertensive anterior uveitis in Korea. Special caution is needed for patients with CMV-induced hypertensive anterior uveitis, considering its adverse effect on the corneal endothelium.
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