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목적 : To determine the diagnostic ability of retinal vessel diameter (RVD) measurements and the factors related to retinal vascular diameters in patients with open-angle glaucoma (OAG).
방법 : This retrospective study included 145 patients with OAG (63 with high-tension and 82 with low-tension glaucoma) and 60 normal controls. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured using IVAN software version 1.3 with dilated 30-degree stereoscopic photographic images. Receiver operating characteristic (ROC) curves were obtained for the average retinal nerve fiber layer (RNFL) thickness and RVD indices including CRAE, CRVE, and CRAE/CRVE ratio. Factors related to CRAE were analyzed by regression analyses in patients with glaucoma.
결과 : Among the RVD indices, the CRAE had the largest AUC for discriminating glaucomatous changes between eyes with glaucoma and those without (0.803; 95% CI, 0.742–0.855). The AUC of CRAE did not differ significantly from that of the average RNFL thickness (P = 0.134). The factors significantly associated with CRAE by both univariate and multivariate regression analyses in glaucoma were age, spherical equivalent, and average RNFL thickness (all P ≤ 0.001).
결론 : The CRAE showed good diagnostic ability for OAG, which was comparable to that of the average RNFL thickness measured using optical coherence tomography. These findings suggest the potential usefulness of RVD for glaucoma detection.
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