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목적 : To measure the juxtapapillary choroidal thickness (JCT) in eyes with normal tension glaucoma (NTG), and to compare it with healthy eyes using swept source (SS) optical coherence tomography (OCT).
방법 : Twelve radial B-scan images of the optic nerve head (ONH) were obtained from 96 patients with NTG and 48 healthy subjects matched by age. The JCT was defined as the average choroidal thickness within 500µm from the border tissue of Elschnig. Choroidal thinning in NTG patients was assessed by calculating the relative choroidal thickness, defined as the ratio of the measured JCT in each meridian to the corresponding value in age-matched healthy controls. Retinal nerve fiber layer (RNFL) damage as reflected by circumpapillary RNFL thickness (measured using spectral-domain OCT) was also assessed.
결과 : The JCT was significantly thinner in NTG eyes than in healthy control eyes in the inferotemporal and superotemporal sectors. The relative choroidal thinning was topographically associated with the hemispheric location of dominant RNFL damage. The average JCT was not associated with either the global RNFL thickness or the visual field mean deviation. Age and untreated intraocular pressure were significantly associated with the JCT in NTG eyes both in univariate and multivariate analyses (all P<0.05).
결론 : Decreased microvascular circulation in the ONH as a result of juxtapapillary choroidal thinning could be an important part of the pathogenesis of optic nerve damage in NTG.
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