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목적 : To determine whether the rate of retinal nerve fiber layer (RNFL) thinning differs according to the presence and structural characteristics of an ODP in primary open-angle glaucoma (POAG).
방법 : A total of 163 eyes with POAG (83 with ODP and 80 without ODP) were included. Optic nerve heads were imaged using swept-source (SS) optical coherence tomography (OCT) to determine the presence of focal lamina cribrosa alteration and its structural characteristics. Eyes with and without both photographic ODP and corresponding microscopic laminar alterations were assigned to the ODP and non-ODP groups, respectively. The rates of progressive thinning of global, and six sectoral spectral-domain OCT RNFL thicknesses were determined by linear regression and compared between the two groups.
결과 : RNFL thinning was faster in the ODP group than in the non-ODP group in the global, temporal-inferior, and temporal sectors (P=.008, P<.001, and P=.003, respectively). The rate of RNFL thinning was maximal in the temporal-inferior sector, and corresponded to the frequency distribution of ODP. Regression analysis revealed that a higher untreated IOP (P=.001), episodes of disc hemorrhage (P≤.003), and the presence of beta-zone parapapillary atrophy (P≤.02) and the presence of ODP (P=.02) were associated with faster global RNFL thinning.
결론 : The presence and structural characteristics of ODPs were associated with both global and focal progression as assessed by the rate of OCT RNFL thinning. The assessment of ODP structure using SS-OCT may help to predict the location of future progression.
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