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목적 : To evaluate the risk of subsequent stroke development following retinal artery occlusion (RAO).
방법 : National registry data were collected from the Korean National Health Insurance Service, comprising 1,025,340 random subjects. Patients diagnosed with RAO in 2002 and 2003 were excluded. The RAO group was composed of patients with an initial diagnosis of either central or other RAO between January 2004 and December 2013 (n = 401). The comparison group was composed of randomly selected patients (five per RAO patient; n = 2,005) who were matched to the RAO group according to sociodemographic factors and year of RAO diagnosis. Each sampled patient was tracked until 2013.
결과 : Stroke occurred in 15.0% of the RAO group and in 7.9% of the comparison group. RAO was associated with an increased risk of stroke occurrence [hazard ratio (HR) = 1.54, 95% confidence interval (CI), 1.14–2.10]. The magnitude of the RAO effect for stroke was larger among younger adults <65 years of age (HR = 2.60), compared to older adults ≥65 years of age (HR = 1.17). However in older adults ≥65 years of age, the risk of subsequent stroke was significantly increased at the 4-year follow-up as a study exit (HR = 1.57, 95% CI, 1.0–2.47).
결론 : RAO was significantly associated with subsequent stroke after adjusting for comorbidities and sociodemographic factors. These findings are limited by uncontrolled confounding factors, and need to be replicated by other observational studies.
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