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목적 : Retinal vein occlusion (RVO) increased the risk of cardiovascular and cerebrovascular morbidity and mortality. However, there has been no study to evaluate the risk of atrial fibrillation (AF) development following RVO until now.
방법 : National registry data were collected from the Korean National Health Insurance Service, comprising 1,025,340 random subjects. The diagnosis of RVO and AF was based on the Korean Classification of Disease codes. The RVO group was composed of patients with a first diagnosis of RVO between January 2003 and December 2007 (n=1,801), excluding those who diagnosed in 2002. The comparison group was composed of randomly selected patients (five per a RVO patient; n=9,005) who were matched to the RVO group according to sociodemographic factors and year of RVO diagnosis. Each sampled patient was tracked
결과 : AF developed in 6.5% of the RVO group and in 4.0% of the comparison group (p<0.001). RVO was significantly associated with an increased risk of AF development in multivariate Cox proportional hazard regression analysis after adjusting for possible confounders [hazard ratio (HR) =1.54; 95% Confidence Interval (CI), 1.25-1.91]. From the subgroup analysis by age and gender, the effect size for AF by RVO were larger in younger adults of <65 years (HR=1.84) than that in older adults of ≥65 years (HR=1.34), and larger in male (HR=2.13) than that in female (HR=1.61) among subjects of <65 years.
결론 : RVO was associated with AF development after adjusting for potential confounders, especially in younger male. These findings were limited to an East Asian population and should be validated by additional observational studies from other ethnics.
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