| 망막F-029 |
| 반대안 분석을 통한 결절성 맥락막혈관병증의 선행병변 연구 |
| 성균관대학교 의과대학 삼성서울병원 안과학교실(1)
서울대학교 의과대학 서울대학교병원 강남센터 안과(2)
연세대학교 의과대학 안과학교실, 시기능 개발연구소(3)
서울대학교 의과대학 분당서울대학교병원 안과학교실(4)
경북대학교 의학전문대학원 안과학교실(5)
경희대학교 의학전문대학원 경희대학교병원 안과학교실(6)
고려대학교 의과대학 안과학교실(7)
충남대학교 의학전문대학원 안과학교실(8)
인제대학교 의과대학 부산백병원 안과학교실(9)
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| 강세웅(1), 김종민(1), 이호영(1), 신주영(2), 배건호(1), 김상진(1), 변석호(3), 박규형(4), 신재필(5), 유승영(6), 오재령(7), 조영준(8), 김현웅(9) |
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목적 : To elucidate precursor lesions of polypoidal choroidal vasculopathy (PCV) by studying the unaffected fellow eyes of patients with active unilateral PCV and comparing them with age-matched control eyes and the unaffected fellow eyes of patients with unilateral typical exudative age-related macular degeneration (AMD).
방법 : This study included the unaffected contralateral eyes of 276 patients in three groups: unilateral PCV (n=154, Group 1), unilateral typical exudative AMD (n=59, Group 2), and unilateral epiretinal membrane (n=63, Group 3) as controls.
Three independent masked observers evaluated fundus photographs, optical coherence tomography images, and indocyanine green angiography images of the three groups. Subretinal or sub-retinal-pigment-epithelial grayish yellow deposits larger than 63 μm in size with irregular but discrete margins were defined as drusen-like deposits (DLD).
결과 : DLDs larger than 125 μm in size were found more frequently in Group 1 (19.5%, P<0.01), than in Group 2 (3.4%) and Group 3 (4.8%). Soft drusen were discovered more frequently in Group 2 eyes (25.4%, P<0.001) than in Group 1 (4.5%) and Group 3 (8.0%). Pigmentary changes on funduscopy and a double layer sign or retinal pigment epithelial undulation on OCT were found more frequently in Groups 1 and 2 compared to Group 3. The frequency of choroidal hyperpermeability and punctate hyperfluorescence spots spatially correlated with DLD were higher in Group 1 than Group 2(P=0.005,P<0.001, respectively)
결론 : The precursor lesions of PCV are different from those of exudative AMD. DLD larger than 125 μm and pigmentary changes may be thought as early preclinical markers of PCV, which may have been formed from previous subclinical or chronic inactive central serous chorioretinopathy, and long-term longitudinal studies are warranted for validation.
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