| 망막F-005 |
| 나이 관련 황반 변성 환자에서 안구 내 아플리버셉과 라니비쥬맙 주사 후 중심와 및 유두주위 맥락막 두께의 변화 |
| 고려대학교 의과대학 안과학교실 |
| 윤철민, 오재령, 안재문, 이보람, 김성우, 허걸 |
|
목적 : To compare changes in subfoveal and peripapillary choroidal thickness (CT) after intravitreal aflibercept or ranibizumab injections for neovascular age-related macular degeneration (AMD).
방법 : Medical records of 54 treatment-naïve, consecutive patients (54 eyes) who were diagnosed with neovascular AMD and received three monthly injections of aflibercept (21 eyes) or ranibizumab (33 eyes) were reviewed. Subfoveal and peripapillary CT were measured with images obtained using spectral domain optical coherence tomography at baseline and at three months.
결과 : Subfoveal CT decreased from 232.2 ± 94.4µm at baseline to 207.1 ± 89.3µm at three months in the aflibercept group (P < 0.001) and from 231.5 ± 102.9µm to 220.0 ± 98.0µm in the ranibizumab group (P = 0.006). Peripapillary CT decreased from 157.2 ± 62.2µm at baseline to 147.4 ± 62.2µm at three months in the aflibercept group (P < 0.001). However, the change in peripapillary CT from 154.9 ± 46.5µm at baseline to 152.3 ± 50.0µm at three months was not significant in the ranibizumab group (P = 0.123)
결론 : Intravitreally injected aflibercept significantly decreased subfoveal CT more than ranibizumab. Choroidal thinning after aflibercept injection was not limited to the subfoveal area, but it extended beyond the macula as well.
|
| |