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목적 : To investigate outcome of combined intravitreal bevacizumab (IVB) and posterior subtenon triamcinolone acetonide injections compared to IVB injection alone in patients with diabetic macular edema (DME).
방법 : IVB injection (IVB group) and combination therapy injection (combination group) were administered to 35 eyes and 31 eyes diagnosed with proliferative diabetic retinopathy (PDR) combined DME, respectively. Changes in best corrected visual acuity (BCVA), central macular thickness (CMT), total macular volume (TMV), amount of hard exudates, and intraocular pressure (IOP) were compared retrospectively between groups pre-injection and 1, 2, and 3 months after injection.
결과 : : BCVA changes in both groups were only statistically significant at week four from injection. Reduction of CMT and TMV was maintained for 1 month after treatment in all groups, but CMT and TMV deteriorated 2 months after treatment. No significant differences in BCVA, CMT or TMV were detected between the IVB group and combination group. The amount of hard exudates were only significantly decreased at month 3 in combination group, whereas the amount of hard exudates exhibited no significant difference at month 3 in IVB group. IOP showed no significant difference between both groups.
결론 : No additive benefit of subtenon triamcinolone was demonstrated in terms of BCVA improvement, CMT, and TMV reduction. However, combined therapy was found to be effective in reduction of amount of hard exudates at 3 months.
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