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목적 : While some studies report that systemic hypertension is a risk factor for glaucoma, other studies indicate that low systemic BP is a risk factor for the development and progression of glaucoma. A direct and clear relationship between glaucomatous damage and BP level has not been established. Moreover, the association between BP and IOP is inconsistent. In the present study, we reviewed the relationship between POAG and BP, focusing on two aspects: hypertension and hypotension.
방법 : The Medline database was used for the literature search in this review. Although every effort was made to use the most recent references possible, articles were used irrespective of the year of publication if deemed appropriate. The key words searched included the following: intraocular pressure, ocular perfusion pressure, glaucoma, blood pressure, circadian fluctuation, and risk factors. After retrieving relevant articles using these key words, a search was conducted through the studies cited in these articles, and additional papers were identified.
결과 : The results of the present study suggest that both high and low BP are associated with an increased risk of POAG based on a comprehensive literature review. Elevated BP is associated with elevated IOP, leading to increased risk of glaucoma, but excessive BP lowering in glaucoma patients may cause a drop in ocular perfusion pressure and subsequent ischemic injury.
결론 : The relationship between IOP, OPP, and BP may be related to a U-shaped relationship between BP and the progression of glaucoma. Therefore, both high and low BP should be monitored with caution especially in patients with progressive glaucoma despite controlled IOP.
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