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목적 : To evaluate the ability to detect diffuse and localized RNFL defects in retinal nerve fiber layer (RNFL) deviation map.
방법 : Eyes of 139 glaucoma patients and 165 healthy subjects were enrolled. All participants were imaged with Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). RNFL defect was defined as at least 10 contiguous red (<1% level) pixels in RNFL deviation map. The area, location, and angular width of RNFL defect were measured automatically. We compared sensitivities, specificities, and area under the receiver operating characteristic curves (AUCs) of RNFL deviation map and cpRNFL thickness in diffuse and localized RNFL defects, respectively.
결과 : In localized defects, the area of RNFL defects (0.991, AUC; 97%, sensitivity; 90%, specificity) in RNFL deviation map showed a higher diagnostic performance (p=0.002) compared to the best cpRNFL parameter (0.914, AUC of inferior RNFL thickness; 79%, sensitivity; 92%, specificity). In diffuse defects, there was no significant difference between RNFL deviation map and cpRNFL parameters. The locations of diffuse RNFL defects were significantly closer to the center of optic disc than localized RNFL defects.
결론 : RNFL deviation map is a useful tool for detecting both diffuse and localized RNFL defects. It has advantages in detecting localized RNFL defect than cpRNFL measurement.
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