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목적 : To investigate the ability of ganglion cell inner plexiform layer (GC-IPL) thickness, measured by spectral domain optical coherence tomography (SD-OCT), to detect progression in glaucomatous subjects.
방법 : Three hundred and eighty-four eyes from 384 patients, followed for an average time of 4.3 years.Average and sectoral GC-IPL thickness and circumpapillary retinal nerve fiber layer thickness were measured by cirrus SD-OCT. The intersession test-retest variabilities of average cRNFL and GC-IPL thicknesses were calculated in 109 stable preperimetric glaucomatous eyes (control group). Optic disc/RNFL photographic assessment and serial visual field (VF) analysis were used as a reference standard for defining overall and central (within 10 degrees) progression.
결과 : Intersession test-retest variabilities were 4.08 um and 1.76 um for average cRNFL and GC-IPL thicknesses, respectively. The sensitivity of GC-IPL thickness for detecting progression ranged from 26.5% to 76.5% using VF criteria, and from 19.1% to 61.0% when using optic disc/RNFL photographic criteria. The specificity ranged from 58.3% to 87.1% using VF criteria. The sensitivity of ≥ 1 sector GC-IPL for detection of central VF progression was significantly higher than that of central RNFL photographic progression (p=0.035).
결론 : GC-IPL parameters with cirrus SD-OCT showed excellent long-term reproducibility and are therefore useful for assessment of glaucoma progression. GC-IPL measurements showed especially better performance than RNFL photographic assessment in detecting central VF progression.
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