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목적 : Retinal vein occlusion (RVO) is commonly associated with conditions such as hypertension, diabetes mellitus, and a wide variety of hematologic disorders. These risk factors for RVO are also risk factors for fatal systemic vascular disease such as cardiovascular or cerebrovascular disease. Several studies have analyzed the association between RVO and cardiovascular disease, and the results have been inconsistent. We investigated the association between RVO and the prospective risk of acute myocardial infraction (AMI) development.
방법 : National registry data were collected from the Korean National Health Insurance Research Database, comprising 1,025,340 random subjects. International Classification of Disease codes were used. Patients with RVO in 2002 were excluded. The RVO group was composed of patients with an initial diagnosis of RVO between 2003 and 2007 (n=1808 in 2003-2007). The comparison group was composed of randomly selected patients (five per RVO patient; n=9040) who were matched to the RVO group according to sociodemographic factors and year of RVO diagnosis. Each sampled patient was tracked until 2013.
결과 : AMI developed in 7.1% of the RVO group and in 5.1% of the comparison group (p<0.001). RVO increased the risk of AMI development in multivariable cox regression [hazard ratio (HR),1.27, 95% Confidence Interval (CI), 1.04-1.55]. In subgroup analysis, RVO patients aged <65 years and male gender in this age group had a 1.38-fold (95% CI, 1.03-1.86) and a 2.04-fold (95% CI, 1.41-2.96) higher risk of AMI development.
결론 : RVO was significantly associated with AMI development after adjusting for potential confounders. These findings are limited by uncontrolled confoundings and need to be replicated by other observational studies.
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