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목적 : To investigate the relationship between cerebrospinal fluid pressure(CSFP), estimated trans-lamina cribrosa pressure difference(TLCPD) and glaucoma.
방법 : We analyzed data on 10,801 eyes who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) 2010-2012. After excluding individuals under 19 years of age, all participants underwent ophthalmic examination, as well as systemic evaluation including blood pressure measurements, body mass index(BMI). Cerebrospinal fluid pressure(CSFP) was calculated as CSPF[mmHg] =0.44 Body Mass Index [kg/m2] +0.16 Diastolic Blood pressure[mmHg] – 0.18 x Age[Years] -1.91. TLCPD was IOP-CSFP.
결과 : Mean estimated CSFP(8.7±3.3 mmHg vs 11.6±3.7 mmHg) was lower, and mean TLCPD( 5.7±4.4 mmHg vs 2.2±4.4 mmHg) was higher in the glaucoma group than in the non-glaucomatous control group. In multivariate analysis, CSFP was associated with younger age, male gender, higher BMI, higher systolic BP in all group and TLCPD was associated with older age, lower BMI, lower systolic BP in all groups. In logistic regression analysis, the odds ratio of a glaucoma diagnosis was less in those with higher CSFP, and more in those with higher TLCP.
결론 : In glaucoma group, there is a potential role for the CSFP and TLCPD in the pathogenesis of glaucomatous optic neurophathy.
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