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목적 : We evaluated the clinical use of macular ganglion cell inner plexiform layer (mGCIPL) thickness versus peripapillary retinal nerve fiber layer (pRNFL) thickness for ethambutol-induced optic neuropathy (EON) diagnosis in affected and nonaffected eyes.
방법 : The study included 154 eyes of 79 patients who complained of visual dysfunctions after taking ethambutol. Among 154 eyes, 121 eyes were in the nonaffected group and 33 eyes were in the EON group. All eyes underwent automated perimetry, color vision test, fundus examination, and optic nerve and macular imaging using spectral domain optical coherence tomography (OCT). Areas under the receiver operating characteristic curve (AUC) values for pRNFL and mGCIPL thicknesses were used to discriminate between eyes with EON and nonaffected eyes.
결과 : The average pRNFL thickness was significantly thinner in the EON group than in the nonaffected group (95.4 ± 11.6 µm vs. 78.5 ± 21.0 µm, P < 0.001), and average mGCIPL thicknesses were also thinner in the EON group than in the nonaffected group (81.3 ± 8.0 µm vs. 59.4 ± 12.8 µm, P < 0.001). The mGCIPL thicknesses showed better correlation with visual field pattern standard deviations (VFPSD) than pRNFL thickness (r2 = 0.402, P < 0.001 vs. r2 = 0.128, P = 0.030). The AUC of average mGCIPL thickness was significantly greater than the average pRNFL thickness (0.931 vs. 0.727, P < 0.001).
결론 : The strong association between visual field severity and GCIPL thickness and the better diagnostic performance of the GCIPL thickness compared with pRNFL thickness in patients with EON provides further evidence that measurement of GCIPL thickness can serve a supplemental tool for diagnosis of EON.
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