| 백굴F-004 |
| Dose-related effect of urinary cotinine levels on cataract among Korean females. |
| 성균관대학교 의과대학 삼성서울병원 안과학교실(1)
가톨릭대학교 대학원 의학과 예방의학교실(2) |
| 임동희(1,2), 정태영(1), 정의상(1), 임현우(2) |
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목적 : It is established that smoking is an important lifestyle risk factor for cataract. However, several studies demonstrated conflicting evidence for a dose-dependent relationship between smoking and cataract. Most of previous studies assessed the smoking status by self-administered questionnaire. Therefore critical information bias might remain in those epidemiologic studies.
To evaluate the dose-dependent relationship, the present study estimated dose-related effects of smoking (urinary cotinine level) on cataract formation by cataract type in females with controlling menopausal status.
방법 : The present study used the ophthalmologic examination dataset of the Korean National Health and Nutrition Examination Survey (KNHANES) IV and V, which was performed between 2008 and 2012. Pre- and postmenopausal females were included in the present study. Individuals with urinary cotinine ≥ 50 ng/mL and self-reported current smoker were defined as continine-verified current smokers. Dose–response relationships between cataract and urinary cotinine levels were estimated using analysis of covariance in pre-menopausal females and postmenopausal females, respectively.
결과 : The association of cataract with urinary cotinine levels was demonstrated with statistical significance in postmenopausal females. For current smoker, a positive effect of cumulative smoking amount on cataract development was shown among Korean female (p < 0.05). In addition, the cataract formation of elderly was greater than that of young ages.
결론 : Our findings suggested a significant dose-related effect of urinary cotinine level with cataract formation among postmenopausal females.
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