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목적 : To determine the characteristics of optic nerve head in a large Korean population based on the data from the nationwide cross-sectional survey, the Korea National Health and Nutrition Examination Survey (KNHANES).
방법 : Data were included from 5,612 participants (≥19 years), who completed a comprehensive glaucoma evaluation (including Goldmann applanation tonometry, fundus photography, and frequency doubling perimetry) in the KNHANES dataset covering January 2012 to December 2012. Two masked graders evaluated fundus photography to detect the loss of neuroretinal rim with vertical cup-disc ratio (VCDR) ≥0.7, violation of the ISNT rule, and retinal nerve fiber layer defect (RNFLD).
결과 : In a total of 5,612 subjects, 292 (5.20%) were diagnosed as glaucoma. The mean VCDR was 0.61 ± 0.19 in glaucomatous subjects, and 0.35 ± 0.11 in non-glaucomatous subjects. In glaucomatous subjects, the prevalence of VCDR ≥0.7 and the violation of the ISNT rule were 63.3% (182 subjects) and 66.8% (195 subjects), respectively. The overall sensitivity, specificity, and AUROC of VCDR ≥0.7 for glaucoma discrimination were 62.7%, 95.6%, and 0.783, respectively. Those of the violation of the ISNT rule were 66.8%, 94.9%, and 0.796, respectively. And, those of RNFLD were 63.7%, 96.2%, and 0.779.
결론 : In the general Korean population, VCDR ≥0.7, RNFLD, and violation of the ISNT rule were associated with greater odds of glaucoma and useful aid to detect glaucoma.
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