| 녹F-048 |
| Association of Vitamin D Status and Open-Angle Glaucoma |
| Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine |
| Jiwon Kim, Tae Keun Yoo, Ein Oh, Chan Yun Kim, Gong Je Seong, Samin Hong |
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목적 : The present study was conducted to test the hypothesis that lower vitamin D status is associated with greater prevalence of open-angle glaucoma (OAG).
방법 : Cross-sectional study. Multivariable logistic regression was performed to examine the relationship between serum 25-hydroxyvitamin D (25(OH)D) and OAG after adjusting for traditional potential confounders. OAG was defined by the criteria of the International Society for Geographical and Epidemiological Ophthalmology.
결과 : Multivariable-adjusted odds ratios of OAG across quintiles of decreasing 25(OH)D were 1.26, 1.00 (reference), 1.31, 1.36 and 1.69 (P for quadratic trend <0.01). The odds ratio for the lowest 25(OH)D quintile was significantly higher than that for the second quintile (P < 0.01). In addition, we discovered that several factors related to OAG, such as intraocular pressure or vertical and horizontal cup-to-disc ratios, had a significant relationship with 25(OH)D level.
결론 : There was a reverse J-shaped association between 25(OH)D levels and the risk of OAG, with significantly elevated risk at lower 25(OH)D. The findings of this research suggest that vitamin D deficiency should be considered as a potential risk factor for the development of OAG.
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