| 이종환¹, 정혜진², 김유정¹, 김응엽³, 김용연⁴, 류택현², 조장희², 김영보², 이종연¹ |
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목적 : To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age and gender-matched controls using ultra-high field 7.0T magnetic resonance imaging (MRI).
방법 : The study included 18 patients with POAG and 18 age-, and sex-matched healthy volunteers. All subjects underwent imaging on a high-resolution 7.0-T MR imaging system. Bilateral LGNs were identified, manually delineated. Peripapillary retinal nerve fiber layer (pRNFL) thickness, optic nerve head parameters including optic disc size, rim area, and cup-to-disc ratio and combined thickness of the ganglion cell layer and inner plexus layer (GC-IPL) were measured by Cirrus high-definition optical coherence tomography (OCT). Correlations between OCT parameters and LGN volume were investigated.
결과 : Mean LGN volumes were significantly smaller in the POAG group than that in the control group (Right, glaucoma 83.97 ± 26.65 mm³ vs. control 106.12 ± 24.32 mm³; Left, glaucoma 65.12 ± 29.41 mm³ vs. control 92.70 ± 24.42 mm³, both p<0.05). In the POAG group, average GC-IPL thickness was correlated with contra-lateral LGN volume (right LGN: r=0.605, p=0.008; left LGN r=0.471, p=0.049). However, there was no correlation between LGN volume and average pRNFL thickness or optic disc parameters in the POAG group.
결론 : On high-resolution 7.0T MRI, LGN volumes in POAG patients are significantly smaller than those of healthy subjects. Furthermore, in patients, LGN volume was found to be significantly correlated with GC-IPL thickness of the contralateral eye.
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