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목적 : To evaluate diagnostic capability of macular ganglion cell-inner plexiform layer (GCIPL) thickness determined by Optical Coherence Tomography in patients with brain lesions.
방법 : Ninety eight patients with brain lesions confirmed by magnetic resonance imaging and 58 healthy subjects were tested by Cirrus optical coherence tomography (OCT) and visual field (VF, Humphrey field analyzer). GCIPL and peripapillary retinal nerve fiber layer (pRNFL) thickness were obtained by Cirrus OCT. Patients were classified into two groups according to the presence of VF abnormality (perimetric (PG) vs. preperimetric (PPG) groups. Areas under the receiver operating characteristic curves (AUCs) of pRNFL and GCIPL thickness were calculated and compared between PG and PPG.
결과 : The pRNFL thickness (84.8 ± 18.2 vs 98.7 ± 6.7 ㎛, p< 0.001) and all GCIPL parameter including average thickness (71.9 ± 8.6 vs 85.1 ± 4.8 ㎛, p<0.001) were significantly thinner in the patient group than control group. The AUCs of average GCIPL thickness was greater than that of pRNFL thickness (0.823 vs 0.941, p<0.001). In the patient group, there was no significant difference in terms of GCIPL parameters for diagnostic capability of brain lesion between PG and PPG (P > 0.05 in all sectors).
결론 : Our result suggested various kinds of brain lesions with different locations showed considerable loss of macular ganglion cells and reduction of GCIPL thickness even before VF abnormality. GCIPL thickness showed better performance than conventional pRNFL thickness in discriminating patient with brains lesions and normal controls.
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