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목적 : To investigate whether the rate of retinal nerve fiber layer (RNFL) thinning differs according to the microstructure of β-zone parapapillary atrophy (PPA) as evaluated by spectral-domain optical coherence tomography (SD-OCT), in primary open-angle glaucoma (POAG).
방법 : Based on the extent of Bruch’s membrane (BM) within the β-zone PPA, as shown in the infrared fundus images, PPA was divided into PPA+BM (PPA with intact BM) and PPA–BM (PPA devoid of BM). Eyes were categorized into group A (having PPA+BM only, n=64), group B (having both PPA+BM and PPA–BM, n=58), group C (having PPA–BM only, n=32), and group D (without β-zone PPA, n=41). The rate of progressive OCT RNFL thinning was determined by linear regression, and compared between groups. Factors influencing the rate of RNFL thinning were evaluated.
결과 : Patients in groups B and C were significantly younger, more myopic, and had greater axial length than those in groups A and D (all P<0.001). The rate of global RNFL thinning was significantly faster in group A (–1.66±2.94μm/year) than in the other groups (group B, –0.87±1.28; group C, 0.20±1.86; group D, –0.28±1.74; P=0.001). Multivariate regression showed a significant association of shorter follow-up period (P=0.016), greater baseline global RNFL thickness (P=0.035), type of β-zone PPA (group A, P=0.023), and greater baseline PPA+BM width (P=0.034) with faster rate of RNFL thinning.
결론 : The rate of RNFL thinning differed according to the microstructure of β-zone PPA. It was faster for eyes with β-zone PPA with intact BM than for those without β-zone PPA or with β-zone PPA devoid of BM.
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