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목적 : To test if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) have an impact on GA progression rates over time in atrophic age-related macular degeneration (AMD).
방법 : Standardized digital FAF images were obtained from 86 eyes of 86 patients with GA using modified fundus camera (excitation, 500–610 nm; emission, 675–715 nm). Areas of GA were quantified and patterns of abnormal FAF in the junctional zone were classified. Repeated FAF images were obtained over a median follow-up period of 2.16 years.
결과 : Areas of GA (median, 11.12 mm2 at baseline) showed a median enlargement of 1.27 mm2 /year. Progression rates in eyes with the banded (median 1.49 mm2/year) and the diffuse FAF pattern (median 1.57 mm2/year) were significantly higher compared to eyes without FAF abnormalities (0.16 mm2/year) and focal FAF patterns (0.59 mm2/year, P<.0001).
결론 : The results indicate that distinct phenotypic FAF patterns have an impact on disease progression in eyes with atrophic AMD and may therefore have prognostic value. The identification of high-risk characteristics will be helpful for treatment aiming at slowing the spread of atrophy.
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