| 발표일자: |
2014년 4월 12일(토) ~ 4월 13일(일) |
| 발표번호: |
P(e-poster)-056 |
| 발표장소: |
킨텍스 제2전시장 7B홀 |
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| Electroretinographic findings associated with selective retina therapy (SRT) versus conventional panretinal photocoagulation (PRP) in rabbits |
| The Catholic University of Korea(1)
Medical Laser Center Lübeck GmbH, Lübeck, Germany(2) |
| Mi Hyun Choi, Young Gun Park, Eric Seifert, Ralf Brinkmann, Young Jung Roh |
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목적 : Subvisible selective retina therapy (SRT) was intended to target the retinal pigment epithelium (RPE) with no thermal damage to the adjacent photoreceptors. To evaluate changes in electroretinographic (ERG) findings after SRT compared to panretinal photocoagulation (PRP) in rabbits.
방법 : One eye of twelve chinchilla rabbits was treated with 150 spots of SRT or conventional laser treatment. Right eyes of six rabbits received SRT(527nm, 21-38uJ, 200um) (SRT group; n = 6) and Right eyes of the other six rabbits were treated with PRP( 577nm,200mW,200um) (PRP group; n = 6). Fluorescein angiography was performed to prove SRT lesions(Figure1). The operated eyes were investigated with full-field ERG according to ISCEV standards at 1hr and at 3 weeks after treatment. The eyes were enucleated at 3 weeks after that, and hematoxylin and eosin staining was employed to monitor.
결과 : At 1 day after treatment, ROD b-wave amplitude was reduced to 64 ± 4 % of baseline in the PRP group compared to baseline and 93 ± 6 % in the SRT group. This reduction was significantly larger in the PRP group than in the SRT group (P <0.05 ; t Test). Similar results were observed for the dark-adapted Combined Response (CR) b-wave amplitude, the reduction in CR b-wave amplitude was significantly larger in the PRP group than in the SRT group. At 3 weeks later, the differences were reduced due to recovery in both PRP and SRT groups. Histology showed selective RPE damage sparing photoreceptors.
결론 : SRT in the rabbit eyes induces less functional loss than PRP group in both rod- and cone-mediated retinal function in full-field ERG. Especially SRT group showed no difference compared to baseline. These results suggest that SRT achieves selective targeting of the RPE without permanent scarring or inner & outer retinal damage.
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