| 발표일자: |
2014년 4월 12일(토) ~ 4월 13일(일) |
| 발표번호: |
P(판넬)-035 |
| 발표장소: |
킨텍스 제2전시장 7B홀 |
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| Therapeutic effect of the caffeic acid phenethyl ester (CAPE) on experimental autoimmune uveoretinitis (EAU) in mice |
| 1. 인제대학교 부산백병원 안신생혈관질환특성화치료센터
2. 인제대학교 의과대학 미생물학교실
3. 인제대학교 부산백병원 안과학교실 |
| 최재혁(1,2), 노국환(1,2), 오하나(1,3), 이지현(1), 송현근(1,2), 양재욱(1,3), 박세광(1,2) |
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목적 : Experimental autoimmune uveoretinitis (EAU) is a T helper type 1 cell-mediated autoimmune disease, which serves as a model of human chronic uveitis. Caffeic acid phenethyl ester (CAPE), an active component of honeybee propolis, has a wide range of beneficial properties. The purpose of this study was to test the therapeutic effect of CAPE in EAU mouse model.
방법 : EAU was induced in C57BL/6 mice by immunization with interphotoreceptor retinoid-binding protein (IRBP) peptide 1-20 and pertussis toxin. CAPE was administered intraperitoneal injection every day (10 mg/kg/day) from day 7 to day 16. Severity of EAU was assessed with clinical scoring using slit lamp microscope, pathology and retinal flat mount.
결과 : CAPE ameliorates the severity of EAU compared with vehicle group. Infiltration of CD4+ T cell was decreased in retina of CAPE-treated EAU mice by IHC while IRBP specific T cell proliferation was not suppressed by CAPE treatment with CFSE labeled T cell proliferation analysis.
결론 : These data suggest that CAPE is a potential therapeutic agent for EAU through its inhibition of CD4 T cell infiltration and macrophage migration.
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