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목적 : To evaluate long term visual outcomes and recurrence of phototherapeutic keratectomy (PTK) for granular corneal dystrophy 2 (GCD2).
방법 : Between 2003 and 2013, 127 eyes of 96 GCD2 patients (Group1, with diffuse stromal haze) and 52 eyes of 41 GCD2 patients (Group2, with exacerbation of granular deposits after refractive surgery) were treated with PTK. Main outcome measures included: best corrected visual acuity (BCVA), spherical equivalent (SE), keratometric central power, keratometric astigmatism, contrast sensitivity values, postoperative complication, and recurrence rate with associated factors.
결과 : The BCVA were 0.45±0.20 (Group1) and 0.46±0.21 (Group2) preoperatively and 0.75±0.18 (Group1) 0.92±0.11 (Group2) postoperatively. The spherical equivalent increased and the contrast sensitivity scores increased after PTK in both groups. During follow-up, recurrences began to occur in 28 eyes (22.0%) and mean recurrence-free interval was 43.1±23.1 months in group 1. In group2, the recurrence developed in 17 eyes (32.7%) and mean recurrence-free interval was 22.6±13.4 months. Factors associated with recurrence were age at PTK in group1 and flap removal in group2 using Cox regression model.
결론 : PTK can increase and maintenance visual outcomes in GCD2 patients with diffuse stromal haze or with exacerbation of granular deposits after refractive surgery. Because of low recurrence rate and safety, PTK may be useful treatment in GCD2.
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