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목적 : To evaluate the relationships between plasma malondialdehyde (MDA) level and ARMS2 variants and phenotypes in patients with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD).
방법 : This study is a retrospective case-control study. Plasma MDA was measured in 84 controls, 62 PCV, and 42 nAMD patients. Participants were genotyped for ARMS2 polymorphism. Phenotypes including bilaterality and greatest linear dimension based on fluorescein angiography (FA-GLD) and indocyanine green angiography (ICGA-GLD), were evaluated.
결과 : Plasma MDA in the PCV and nAMD groups were higher than the control (P<0.001). For ARMS2 variants, plasma MDA of homozygous high-risk genotype were higher than homozygous low-risk genotype in all groups (P<0.001). Plasma MDA was higher in homozygous high-risk genotype than heterozygous genotype in control, PCV, and nAMD, for ARMS2. In the nAMD, there was a correlation between plasma MDA and both FA-GLD (r=0.418, P=0.006) and ICGA-GLD(r=0.329, P=0.033). There was a difference in plasma MDA between patients with unilateral and bilateral lesions in both PCV and nAMD.
결론 : This study revealed significant relationships between plasma MDA level and ARMS2 variants and phenotypes in PCV and nAMD.
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