| 발표일자: |
2013년 11월 1일(금) ~ 11월 3일(일) |
| 발표번호: |
P(e-poster)-130 |
| 발표장소: |
킨텍스 제2전시장 7B홀 |
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| 당뇨망막병증에서 Tonicity Response Element Binding Protein (TonEBP)과 신경세포사멸와 연관성 |
| 1 경상대학교 의학전문대학원 안과학교실
2 경상대학교 의학전문대학원 해부학교실
3 경상대학교 건강과학원 |
| 김성재1, 3, 조용운1, 정인영1, 3, 최완성2, 3, 유지명1, 3 |
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목적 : Diabetic retinopathy is severe complication leading to visual dysfunction. The present study addressed the contribution of tonicity response element binding protein (TonEBP) to retinal cell death in diabetic retinopathy (DR).
방법 : Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/Kg streptozotocin (STZ). Control mice received vehicle (phosphate-buffered saline). All mice were killed 2 months after injections, and the extent of cell death, TonEBP and aldose reductase (AR) protein expression levels were examined.
결과 : The TonEBP and AR protein levels and the death of retinal ganglion cells (RGCs) were significantly increased in the retinas of diabetic mice compared with controls 2 months after induction of diabetes. Terminal deoxy-nucleotidyl transferase (TdT) - mediated dUTP nick end labeling (TUNEL)-positive signals co-localized with TonEBP immunoreactive RGCs.
결론 : The present data show that AR and TonEBP are upregulated in DR and TonEBP may contribute to apoptosis of retinal neurons in the DR.
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